Lipid Profile in ‘Newly Diagnosed’ and ‘On Treatment’ Hypothyroid
Published: October 1, 2011 | DOI: https://doi.org/10.7860/JCDR/2011/.1551
RAVI SHEKHAR, SRINIVAS C.H., M.C. DAS
Corresponding Author.
Assistant Professor, Department of Physiology
NRI Medical College, Guntur, Andhra Pradesh, India.
Professor, Dept of Pharmacology,
NRI Medical College, Guntur, Andhra Pradesh, India.
Correspondence
Ravi Shekhar
Associate Professor
Department of Biochemistry
NRI Medical College
Chinakakani, Guntur District,
Andhra Pradesh -522503.
Phone: 9849702360.
E-mail: ravishekhar1974@yahoo.com
Introduction: Primary hypothyroidism is a common disorder affecting a large group of population and is a cause of the secondary hyperlipidemia. The aim of the present study was to assess the relation between the lipid profile and thyroid profile in newly diagnosed hypothyroid, subjects on treatment for hypothyroidism and controls.
Materials and Methods: The present study was performed on 150 subjects of both sexes between 11–78 years of age. The subjects were divided into three groups. First group was Controls (n = 50), second group was ‘Newly Diagnosed’ hypothyroid (n = 50) and the third group was hypothyroid patients‘On Treatment’ (n = 50). T3, T4, TSH, Total Cholesterol, High Density Lipoproteins (HDL), Low Density Lipoproteins (LDL) and Triglycerides were estimated.
Results: ANOVA was calculated among the three groups. TSH, Total Cholesterol and LDL levels were decreased in “On treatment” group when compared to “Newly diagnosed” group. T4 was found to be elevated, but T3 remained low in “On treatment” group.
Conclusion: Cholesterol and LDL levels are elevated in hypothyroidism and their levels decreases with treatment but not to the level of euthyroid state.
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